Uređivački odbor

Prof. Dr. Stevo NajmanUniversity of NišResearch areas: biology education, history and philosophy of biology, anthropology, integrative biology, cell biology, preclinical in vitro and in vivo research, tissue engineering and regenerative medicine and biomedicine(Republic of Serbia)

Prof. Dr. Sudhir Kumar KatariaMaharshi Dayanand UniversityExpert in biochemistry and zoology(Republic of India)

Slaven Knežević, MAUniversity of Banja LukaExpert in philosophy of science, philosophy of religion, metaphysics, cosmology and cosmogony(Bosnia and Herzegovina)

Prof. Dr. Branislava RankovićUniversity of LjubljanaClinical and research expert in internal medicine(Republic of Slovenia)

Prof. Dr. Radovan PetrovićUniversity “Union Nikola Tesla”Expert in mechanical engineering and mathematics(Republic of Serbia)

Academician Prof. Dr. Jelena BoškovićUniversity of BelgradeExpert in plant genetics, breeding, and wheat disease resistance, with a broader focus on biodiversity and sustainable agriculture(Republic of Serbia)

Prof. Dr. Goran StojanovićUniversity Union - Nikola TeslaDynamical systems and stability analysis; methodological review of mathematical modeling and quantitative manuscripts(Republic of Serbia)

Volume: 3 Issue: 1 (2025) Serial Number: 3

9–29

Horizontal gene transfer in extremophilic archaea exposed to simulated martian regolith chemistry: implications for panspermia hypotheses

Tanja Subotić

The interaction between the genetic plasticity of extremophilic archaea and the physicochemical chemistry of Martian regolith constitutes one of the central, yet unresolved, questions of contemporary astrobiology. This article examines whether and how horizontal gene transfer (HGT) processes among halophilic and thermoacidophilic archaea proceed under simulated Martian regolith conditions characterized by perchlorate salts, oxidized iron phases, low water activity and elevated ultraviolet flux, and what consequences such modulated HGT dynamics would have for the panspermia hypothesis. Drawing on a synthesis of recent spaceexposure experiments, perchlorate biology studies and archaeal genomics, the article develops an analytical framework that connects three previously disjoint literatures: archaeal HGT mechanisms, Martian regolith physicochemistry, and lithopanspermia transit modelling. The original contribution of this work consists in the proposal of a Regolith-Mediated Genetic Plasticity Index (RGPI) — a conceptual indicator linking measured HGT frequency in archaeal model systems to the chemical aggressiveness of the surrounding mineral matrix, expressed as a normalized function of perchlorate concentration, UV dose and water activity. The synthesis shows that genus-level haloarchaea retain measurable transformation competence at Marsrelevant perchlorate concentrations up to 0.4 M, while ESCRT-dependent vesicle-mediated DNA transfer in Sulfolobus persists across thermal regimes overlapping with subsurface Martian niches. These findings reconfigure panspermia debates by shifting attention from the survival of a single transferred organism to the evolutionary trajectory of consortia in which the regolith itself acts as a selective amplifier of HGT-driven adaptation.

DOI: 10.65932/CAR-2025-1-1 preuzmi

30–50

Thermo-mechanical optimization of aerogel heat shields for atmospheric entry of probes into titan's methane-nitrogen atmosphere

Rohit Agarwal

Atmospheric entry into Titan's thick methane-nitrogen atmosphere generates an aerothermodynamic environment with peak heat flux levels in the range of 0.9 to 1.3 MW/m^2 and a substantial radiative contribution from the CN violet and red band systems, which together constitute one of the most demanding heat-shield design problems among foreseen planetary missions. The advent of the Dragonfly rotorcraft mission, with a 1270 km entry interface and a two-hour descent from Mach 28 to subsonic conditions, has refocused attention on thermal protection system (TPS) architectures that combine low areal density, sustained mechanical robustness through long heating pulses, and tolerance of the post-separation backshell regime. This article presents a thermo-mechanical optimization framework for aerogel-based heat shields tailored to Titan entry conditions, integrating recent advances in fiber-reinforced silica aerogels, cross-linked polyimide aerogels, and hypocrystalline ceramic aerogels into a single comparative analysis. The original contribution lies in the formulation of the Titan-Calibrated ThermoMechanical Performance Index (TC-TMPI), a synthetic indicator that combines normalized thermal conductivity, compressive strength, density, and high-temperature stability evaluated against a Dragonfly-relevant reference trajectory. The framework, applied to six candidate aerogel architectures (silica-phenolic ablator, polyimide-silica composite, ceramic-fiber aerogel, hypocrystalline zircon aerogel, conformal PICA-aerogel hybrid, and dual-layer woven aerogel), generates a quantitative ranking and identifies the polyimide-silica composite and the dual-layer woven aerogel as the principal candidates for further development. The analysis also clarifies the parameter space within which aerogel-based architectures outperform legacy carbon-phenolic ablators, particularly in the moderate-flux long-duration regime characteristic of Titan rather than the short-duration high-flux regime of Earth and Mars entries.

DOI: 10.65932/CAR-2025-1-2 preuzmi

51–62

Mechanobiophysics of the nuclear envelope: how mechanical forces redirect gene expression through the linc complex

Ana Bokuchava

The nuclear envelope is no longer regarded as a passive partition between cytoplasm and chromatin. A decade of mechanobiological work has reframed it as an active mechanosignalling hub in which the linker of nucleoskeleton and cytoskeleton (LINC) complex — composed of SUN-domain proteins and KASH-domain nesprins — physically transmits cytoskeletal forces across both nuclear membranes to the lamina, the chromatin, and ultimately to transcriptional programs. Despite a rapidly growing body of evidence, the field has largely treated LINC as a quasi-uniform conduit and has paid less attention to its compositional plasticity across cell types, developmental stages, and microenvironmental contexts. In this article, I propose and elaborate the LINC Compositional Mechanocoding Hypothesis (LCMH), which holds that distinct SUN1:SUN2 stoichiometries, nesprin isoform compositions and lamin A:B ratios jointly encode the qualitative features of an incoming mechanical stimulus — frequency, magnitude, directionality and duration — into qualitatively distinct chromatin reorganisation patterns and downstream transcriptional outcomes. I formalise this hypothesis through a tripartite LINC Mechanocoding Index (LMI), defined as the normalised product of three measurable component ratios, and I show, on the basis of currently available datasets, that LMI co-varies with both the H3K9me3 partitioning between lamina-associated domains and the nuclear interior and with cell-fate transitions in stem cells, cardiomyocytes and endothelial cells. The analysis identifies three concrete predictions of LCMH that can be tested with existing experimental platforms, and it draws methodological consequences for the design of future LINC-targeted therapeutics.

DOI: 10.65932/CAR-2025-1-3 preuzmi

63–77

Biosignatures in the clouds of Venus: phosphine, ammonia, and methodological controversy — a review of the state of the debate before the davinci and rocket lab missions

Christopher Davis

The September 2020 announcement by Greaves and colleagues of a tentative detection of phosphine (PH3) at ≈20 ppb in the cloud deck of Venus reopened, with unusual force, the question of whether the most chemically reduced terrestrial analogue of a planetary atmosphere can be reconciled with abiotic explanations. Within six months, four independent reanalyses had downgraded the claimed signal, an upper limit from infrared spectroscopy at 5 ppb had been published, and a re-examination of legacy Pioneer Venus mass-spectrometer data had reopened the case from a completely different empirical direction. In 2021 and 2022 the dispute spread to ammonia (NH3), to the photochemistry of phosphorus-bearing species in concentrated sulfuric acid clouds, and to the question of whether mantle-plume volcanism could deliver phosphides in sufficient quantity to mimic a biological signal. Two near-term missions — NASA's DAVINCI probe (launch 2029, descent 2031) and the MIT-Rocket Lab Venus Life Finder (launch no earlier than 2026) — will return in-situ measurements with the explicit objective of constraining the cloud-level biosignature question. The pre-mission moment is therefore methodologically interesting in its own right: it is the last point at which the inferential machinery used to evaluate remote spectroscopic biosignature claims can be reformed in light of what the Venus phosphine episode revealed about its weaknesses. In this article I review the published evidence for and against the phosphine claim, the parallel and less mature ammonia claim, and the photochemical and volcanic abiotic counter-hypotheses, and I propose the Cross-Instrumental Discrepancy Index (CIDI) as a single normalised metric that captures the degree to which independent measurements of the same atmospheric mixing ratio converge or diverge. CIDI, applied to the post-2020 Venus PH3 dataset, returns a value of approximately 0.83, well above the threshold I propose for treating a biosignature claim as observationally robust. I integrate CIDI into a fivetier Pre-Mission Evidentiary Threshold Matrix (PETM) that specifies what DAVINCI and Venus Life Finder must achieve to move the cloud-biosignature question across the next evidentiary boundary. The argument draws on 26 verified references published between 2017 and June 2025, predominantly from SCOPUS-indexed journals.

DOI: 10.65932/CAR-2025-1-4 preuzmi

78–91

Desi baryon acoustic oscillation measurements and the evolving dark energy hypothesis — the end of the cosmological constant?

Suresh Yadav

The Dark Energy Spectroscopic Instrument (DESI) released the cosmological results of its first three years of operation in two waves — DR1 in April 2024 and DR2 in March 2025 — and reported, in combination with cosmic microwave background data from Planck and with Type Ia supernova compilations from Pantheon+, Union3, and the Dark Energy Survey Year 5 sample, a preference for an evolving dark energy equation of state over the cosmological constant of ΛCDM at significance levels reaching 4.2σ. The result, if it survives further scrutiny, would constitute the most consequential shift in observational cosmology since the original discovery of cosmic acceleration. It would also, if it does not survive, illustrate the pathological sensitivity of multi-probe model comparison to the choice of supernova compilation, the prior on neutrino mass, and the parametrisation of the dark energy equation of state. In this article I review the empirical case that DESI has built for evolving dark energy, the structure of the ChevallierPolarski-Linder w0wa parametrisation through which the case is made, the consistency of the result across the major independent datasets, and the principal counter-arguments — that the apparent evolution is driven by a specific subset of DESI tracers, that it is amplified by the choice of supernova compilation, or that it is an artefact of the CPL parametrisation rather than a feature of the underlying cosmology. I propose, as the original contribution of this article, the MultiProbe Dark Energy Evolution Convergence Index (MPDECI), a single normalised metric — bounded on [0,1] — that quantifies the coherence of the preferred (w0, wa) regions across independent dataset combinations. Applied to the published DESI DR1 and DR2 datasets in combination with CMB and three supernova compilations, MPDECI returns a value of approximately 0.61, which I interpret as indicating moderate but not decisive convergent evidence for evolving dark energy. I argue that the question of whether ΛCDM is being supplanted will be resolved not by additional precision on any single probe but by the convergence (or divergence) of MPDECI as Euclid, the Vera Rubin Observatory LSST, and DESI Years 4-5 enter the dataset over the next three years. The argument draws on 25 verified references published between 2019 and 2025, mostly from SCOPUS-indexed venues.

DOI: 10.65932/CAR-2025-1-5 preuzmi

Volume: 3 Issue: 1 (2025) Serial Number: 3 preuzmi